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KMID : 1140120120170020095
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Cancer Prevention Research
2012 Volume.17 No. 2 p.95 ~ p.99
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Phloroglucinol Protects Cells against Streptozotocin-induced Oxidative Stress in Rat Pancreatic β-cell RINm5F
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Kim Areum-Daseul
Kang Min-Ji
Ko Mi-Sung
Yang Hye-Won
Jang Won-E
Choi Hyeon-Ui
Hyun Jin-Won
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Abstract
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Streptozotoxin-induced oxidative cell damage-mediated apoptosis plays an important role in the destruction of pancreatic β-cells and contributes to the development of diabetes. In the present study, protective effect of phloroglucinol (1,3,5-trihydroxybenzene) on streptozotocin (STZ)-induced oxidative cell damage was investigated in rat pancreatic β-cells, RINm5F. Phloroglucinol was significantly decreased the level of STZ-induced intracellular reactive oxygen species (ROS) and reduced STZ-induced loss of the mitochondrial membrane potential. Phloroglucinol enhanced cell viability against STZ-induced cell damage and inhibited STZ-induced apoptotic cell death, confirmed by formation of apoptotic bodies and sub G1 phase. These results suggest that phloroglucinol exhibits protective effects on STZ-induced oxidative cell damage-mediated apoptosis in rat RINm5F pancreatic β-cells.
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KEYWORD
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Phloroglucinol, Oxidative stress, Reactive oxygen species, RIN5mF cells
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